Resources for using CLEVIPREX® (clevidipine)Access on-demand videos and downloadable resources with information about CLEVIPREX and the treatment settings where using CLEVIPREX may be appropriate.
CLEVIPREX resources for your care team
Stroke Guidelines Summary
Download a summary of the 2018 AHA/ASA AIS Guidelines recommendations on CLEVIPREX.
Download a PDF overview of helpful information about CLEVIPREX.
CLEVIPREX video resource library
The pharmacology of CLEVIPREX1
CLEVIPREX is titrated to the desired reduction in BP. The eﬀect of CLEVIPREX appears to plateau at approximately 25% of baseline systolic pressure. The infusion rate for which half the maximal eﬀect is observed is approximately 10 mg/h.
Mechanism of action1
CLEVIPREX works by selectively dilating arterial smooth muscle via calcium channel blockade, reducing systemic vascular resistance without aﬀecting preload.
Dosing and Administration1
CLEVIPREX oﬀers non–weight-based dosing and is not dependent on hepatic or renal function. The ready-to-use vials are available in 50 and 100 mL for individualized, titratable administration.
Peer insight videos
Renowned anesthesiologist Dr. Todd Horowitz discusses CLEVIPREX clinical trial results and dosing in a series of informative videos for healthcare professionals.
CLEVIPREX Clinical Trials
Dr. Todd Horowitz discusses eﬃcacy and safety outcomes from pivotal trials in a variety of patient types and settings.
Get an overview of how to properly administer and dose CLEVIPREX presented by Dr. Todd Horowitz.
Low-volume dosing with CLEVIPREX1
Watch a video featuring Dr. Solomon Aronson, lead investigator of the ECLIPSE trials, as he discusses the trials and how CLEVIPREX was studied against active comparators. Learn how CLEVIPREX drug administration in the trial compared with nicardipine in the postoperative setting.
References: 1. CLEVIPREX® (clevidipine) Prescribing Information. 2021. 2. Aronson S, Dyke CM, Stierer KA, et al. The ECLIPSE trials: comparative studies of clevidipine to nitroglycerin, sodium nitroprusside, and nicardipine for acute hypertension treatment in cardiac surgery patients. Anesth Analg. 2008;107(4):1110-1121.
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