CLEVIPREX® (clevidipine) has individualized, titratable dosing
Low-volume, non–weight-based dosing1
- Administered intravenously by a dedicated central or a dedicated peripheral line
- Single-use parenteral emulsion* that contains 0.005% EDTA to inhibit the rate of growth of microorganisms for up to 12 hours
- Metabolized by esterases in the blood and extravascular tissues
- Elimination is unlikely to be affected by hepatic or renal dysfunction
*CLEVIPREX contains approximately 0.2 g of lipid per mL (2.0 kcal).
50 mL vial lasts
100 mL vial lasts
†Most patients will achieve the desired therapeutic response at approximately 4–6 mg/hr.
Individualized, titratable administration1
- Initiate intravenous CLEVIPREX infusion at 1–2 mg/hr (2–4 mL/hr)
- This includes patients with abnormal hepatic function and moderate to severe renal impairment
- Individualize dosage depending on the response of the patient and the BP goal
- Most patients were treated with maximum doses of 16 mg/hr or less
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- Dose may be doubled every 90 seconds initially
- As BP approaches goal:
- Increase dose by less than double
- Lengthen time between dose adjustments to every 5–10 minutes
- An approximately 1–2 mg/hr (2–4 mL/hr) increase will generally produce an additional 2–4 mmHg decrease in SBP
- Most patients achieve desired therapeutic response at 4–6 mg/hr (8–12 mL/hr)
- Severe hypertension may require doses up to 32 mg/hr (64 mL/hr), but there is limited experience at this dose rate
- Monitor blood pressure and heart rate continually during infusion, and then until vital signs are stable
- Patients who receive prolonged CLEVIPREX infusions and are not transitioned to other antihypertensive therapies should be monitored for the possibility of rebound hypertension for at least 8 hours after the infusion is stopped. These patients may need follow-up adjustments in BP control
Optimizing CLEVIPREX administration1
- Maintain strict aseptic technique
- Inspect package and bottle for any defects and bottle contents for particulate matter, discoloration, or contaminants; do not use if contamination is suspected
- Invert vial gently several times before use to ensure uniformity of the emulsion
- Once stopper is punctured, use within 12 hours and discard any unused portion
- Because CLEVIPREX is a low-volume infusion, it is crucial to prime the IV tubing and check for dead space
- Manage lack of response
- Ensure CLEVIPREX is getting to the patient by checking for dead space
- Individual patient response may vary
- Note rapid onset and offset of CLEVIPREX when changing the IV set or vial
Dr. Horowitz speaks about CLEVIPREX
Renowned anesthesiologist Dr. Todd Horowitz discusses CLEVIPREX clinical trial results and dosing in a series of informative videos for healthcare professionals.