CLEVIPREX® (clevidipine) Additional dosing, storing, and handling information

Cleviprex Vials

No experience of overdosage in human clinical trials1

  • The expected major effects of overdosage would be hypotension and reflex tachycardia

In case of suspected overdosage, CLEVIPREX should be discontinued immediately, and the patient’s BP should be supported.

  • Discontinuation of CLEVIPREX leads to a reduction in antihypertensive effects within 5 to 15 minutes
CLEVIPREX single-use, ready-to-use vials

Maximum dose1

  • Most patients treated with maximum doses of 16 mg/h (32 mL/h) or less
  • There is limited short-term experience with doses as high as 32 mg/h (64 mL/h)
  • Because of lipid load restrictions, no more than 1000 mL or an average of 21 mg/h (42 mL/h) of CLEVIPREX infusion is recommended per 24-hour period
  • There is little experience with infusion durations beyond 72 hours at any dose

CLEVIPREX is Y-site compatible with several IV bag fluids1

Y-Site IV Fluid Bag

Considerations when using a Y-site to administer CLEVIPREX

  • Do not dilute CLEVIPREX
  • Do not administer CLEVIPREX in the same line as other medications

Compatible IV bag fluids include:

  • Water for Injection, USP
  • 0.9% Sodium Chloride Injection, USP
  • 5% Dextrose Injection, USP
  • 5% Dextrose in 0.9% Sodium Chloride Injection, USP
  • 5% Dextrose in Lactated Ringer’s Injection, USP
  • Lactated Ringer’s Injection, USP
  • 10% Amino Acid

Storage and handling considerations for CLEVIPREX1

Light Icon

Light sensitivity

CLEVIPREX is photosensitive; leave vials in cartons until use

  • Protection from light during administration is not required

CLEVIPREX Dosing and Administration Guide

Use this guide as a quick reference to help with CLEVIPREX dosing and administration.


Download the Guide
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CLEVIPREX Dosing and Administration Guide

Use this guide as a quick reference to help with CLEVIPREX dosing and administration.

Dosing and Admin Guide thumbnail

The CLEVIPREX Dosing and Administration Guide

Use this guide as a quick reference to help with CLEVIPREX dosing and administration.

Download the Guide

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Ordering Information

View professional resources

See downloadable resources and videos intended to support CLEVIPREX prescribers and staff.
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