CLEVIPREX® (clevidipine) has individualized, titratable dosing and administration

Learn about CLEVIPREX® (clevidipine) titratable dosing

Low-volume, non-weight-based dosing1

  • Administered intravenously by a dedicated central or a dedicated peripheral line
  • Single-use parenteral emulsion* that contains 0.005% EDTA to inhibit the rate of growth of microorganisms for up to 12 hours
  • Metabolized by esterases in the blood and extravascular tissues
    • Elimination is unlikely to be affected by hepatic or renal dysfunction

*CLEVIPREX contains approximately 0.2g of lipid per mL (2.0 kcal).

50 mL and 100 mL CLEVIPREX single-use vials

Dosage forms and strengths

  • 50 mL and 100 mL single-use vials
  • Concentration: 0.5 mg/mL

Individualized, titratable administration1

Initiate Icon


  • Initiate intravenous CLEVIPREX infusion at 1–2 mg/hr (2–4 mL/hr)
    • This includes patients with abnormal hepatic function and moderate to severe renal impairment
  • Individualized dosage depending on the response of the patient and the BP goal
  • Most patients were treated with maximum doses of 16 mg/hr or less
Cleviprex Dosing Calculator
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64 mL/hr

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Titrate Icon


  • Dose may be doubled every 90 seconds initially
  • As BP approaches goal:
    • Increase dose by less than double
    • Lengthen time between dose adjustments to every 5–10 minutes
  • An approximately 1–2 mg/hr (2–4 mL/hr) increase will generally produce an additional 2–4 mmHg decrease in SBP
  • Most patients achieve desired therapeutic response at 4–6 mg/hr (8–12 mL/hr)
    • Severe hypertension may require doses up to 32 mg/hr (64 mL/hr), but there is limited experience at this dose rate

Monitor Icon


  • Monitor blood pressure and heart rate continually during infusion, and then until vital signs are stable
  • Patients who receive prolonged CLEVIPREX infusions and are not transitioned to other antihypertensive therapies should be monitored for the possibility of rebound hypertension for at least 8 hours after the infusion is stopped. These patients may need follow-up adjustments in BP control


Maximum dose

  • Most patients treated with maximum doses of 16 mg/hr (32 mL/hr) or less
  • There is limited short-term experience with doses as high as 32 mg/hr (64 mL/hr)
  • Because of lipid load restrictions, no more than 1,000 mL or an average of 21 mg/hr (42 mL/hr) of CLEVIPREX infusion is recommended per 24-hour period
  • There is little experience with infusion durations beyond 72 hours at any dose

Optimizing CLEVIPREX administration1

Before Administration

During Administration

  • Maintain strict aseptic technique
  • Inspect package and bottle for any defects and bottle contents for particulate matter, discoloration, or contaminants; do not use if contamination is suspected
  • Invert vial gently several times before use to ensure uniformity of the emulsion
  • Once stopper is punctured, use within 12 hours and discard any unused portion
  • Because CLEVIPREX is a low-volume infusion, it is crucial to prime the IV tubing and check for dead space
  • Manage lack of response
    • Ensure CLEVIPREX is getting to the patient by checking for dead space
    • Individual patient response may vary
  • Note rapid onset and offset of CLEVIPREX when changing the IV set or vial

Watch the CLEVIPREX dosing and administration video

Watch the whole video, or select a chapter for more specific information.

The CLEVIPREX dosing and administration guide

Use this guide as a quick reference to help with CLEVIPREX dosing and administration.

Reference Guide of CLEVIPREX

Transitioning off CLEVIPREX

Learn what to consider when transitioning patients off CLEVIPREX.

Demonstrated safety profile

The safety profile of CLEVIPREX was evaluated in multiple randomized studies1